A slow unfolding at double speed. Therapeutic interventions with parents and their young children.

Book Synopsis. This volume is the result of over twenty years of therapeutic interventions with families within the Tavistock Clinic's Under Fives Service. It describes in detail the process of understanding young children's communications and behaviour and the dynamics of family relationships within the consulting room in a lively, accessible style. It covers common themes in work with young children such as disruptive, angry behaviour, separation and sleep difficulties, and problems in the parent/couple relationship. This book is essential reading for all early years professionals hoping to gain a greater understanding of the technique, observational skills and theory which underlie a psychodynamic approach to work with the under fives

Observation, reflection and containment: A psychoanalytic approach to work with parents and children under five.

The contemporary relevance of psychoanalysis is being increasingly questioned; Off the Couch challenges this view, demonstrating that psychoanalytic thinking and its applications are both innovative and relevant, in particular to the management and treatment of more disturbed and difficult to engage patient groups. Chapters address: clinical applications in diverse settings across the age range the relevance of psychoanalytic thinking to the practice of CBT, psychosomatics and general psychiatry the contribution of psychoanalytic thinking to mental health policy and the politics of conflict and mediation. This book suggests that psychoanalysis has a vital position within the public health sector and discusses how it can be better utilised in the treatment of a range of mental health problems. It also highlights the role of empirical research in providing a robust evidence base. Off the Couch will be essential reading for those practicing in the field of mental health and will also be useful for anyone involved in the development of mental health and public policies. It will ensure that practitioners and supervisors have a clear insight into how psychoanalysis can be applied in general healthcare

An investigation of visitor and resident place perceptions of Mid Wales, and an evaluation of the potential of such perceptions to shape economic development in the area

The research investigates visitor and resident place perceptions of Mid Wales and evaluates the potential of such perceptions to shape economic development in the area. A review of literature indicated a need for an holistic approach to place. It was suggested that a starting point towards achieving this is to envisage place as three components - the real, the expected and the perceived. The real place is described using secondary statistical information and maps of the area. the expected place is described using topographical writing and guide books. The perceived place is examined through a combination of questionnaires and interviews with residents and visitors. These investigate perceptions of the landscape and economy of Mid Wales. The 'perceived places' of residents and visitors are described. A number of agencies based in Mid Wales were also interviewed to examine i) their perceptions of Mid Wales' ii) the way in which visitor and resident perceptions are incorporated into the policy development process, and, iii) their responses to some of the preliminary outcomes of the research. The research concluded that both residents and visitors have well defined, but different place perceptions of Mid Wales. Visitor perceptions are more affected by the expected place than the real, whilst resident perceptions are more affected by the real place than the expected. There are currently few mechanisms by which place perceptions are directly incorporated into the development process. However, the place perceptions of agencies were found to be close to those of the groups they represented; it is suggested that place perceptions are fundamental truths shared by groups, which are so strong as to actually subconsciously drive the policy development process. Policy implications are suggested, as are ideas for future research

Engaging Communities in their Heritage: Collaboration between Higher Education and the Voluntary Sector in Wales and Ireland

The paper focuses on an Interreg funded pilot project entitled ‘Heritage and Culture for Learning, Empowerment and Sustainable Tourism’.  The project was a collaborative development between a Higher Education Institution in Wales and a Voluntary Sector Organisation in Ireland and adopted an innovative approach to engaging communities in their heritage.  The central aim of the project was to develop and promote joint opportunities for the creation of sustainable tourism products which build on the natural assets (people and landscape), built assets, culture and heritage of the Wales Ireland cross border region.  In practice this was achieved through an innovative approach combining research, lifelong learning, higher level skills development, networking, marketing and business development through active engagement of local communities. The pilot project ended in July 2013, and the focus of this presentation is an evaluation of the project outcomes and experiences.Le document met l'accent sur un projet pilote financé par Interreg intitulé «Patrimoine et Culture pour l'apprentissage, autonomisation et tourisme durable ». Le projet a été l’aboutissement d’un travail collaboratif entre un établissement d'enseignement supérieur au Pays de Galles et un organisme du secteur bénévole en Irlande et a adopté une approche novatrice de l'engagement des communautés dans leur patrimoine. L'objectif central du projet était de développer et de promouvoir les possibilités communes de collaboration pour la création de produits de tourisme durable qui s'appuient sur les ressources naturelles (personnes et paysage), de patrimoine bâti, de la culture et du patrimoine de la région transfrontalière du Pays de Galles-Irlande. Dans la pratique, cela a été réalisé grâce à une approche innovante combinant la recherche, la formation continue, le développement des compétences de plus haut niveau, le réseautage, le marketing et le développement des entreprises grâce à l'engagement actif des communautés locales. Le projet pilote a pris fin en Juillet 2013, et la mise au point de cette présentation est une évaluation des résultats et des expériences du projet.يركز هذا البحث على مشروع تجريبي مموَّل من طرف برنامج التعاون الأوروبي العابر للحدود (Interreg) بعنوان: "التراث والثقافة من أجل التعلم، التمكين و السياحة المستدامة." اعتمد المشروع على عمل تعاوني بين معهد التعليم العالي ببلاد الغال و منظمة تابعة للقطاع التطوُّعي بإيرلندا معتمدين على مقاربة مجددة لإشراك المجتمعات في تراثها.كان الهدف الرئيسي من المشروع هو تطوير وتعزيز الفرص المشتركة لخلق منتجات سياحية مستدامة، والتي تعتمد على الثروات الطبيعية (أشخاص ومناظر طبيعية)، التراث المعماري بالإضافة إلى الثقافة والتراث في المنطقة الحدودية بين بلاد الغال وإيرلندا. عمليا، تحقق ذلك من خلال مقاربة مبتكرة جمعت بين البحث، والتعلم المتواصل، وتنمية المهارات على أعلى مستوى، والربط الشبكي، والتسويق وتطوير الأعمال من خلال المشاركة الفعالة للمجتمعات المحلية. انتهى المشروع التجريبي في جويلية2013، ويركز هذا العرض على تقييم نتائجه والخبرات المستفادة منه

Vertebrate TFPI-2 C-terminal peptides exert therapeutic applications against Gram-negative infections

Background: Tissue factor pathway inhibitor-2 (TFPI-2) is a serine protease inhibitor that exerts multiple physiological and patho-physiological activities involving the modulation of coagulation, angiogenesis, tumor invasion, and apoptosis. In previous studies we reported a novel role of human TFPI-2 in innate immunity by serving as a precursor for host defense peptides. Here we employed a number of TFPI-2 derived peptides from different vertebrate species and found that their antibacterial activity is evolutionary conserved although the amino acid sequence is not well conserved. We further studied the theraputic potential of one selected TFPI-2 derived peptide (mouse) in a murine sepsis model. Results: Hydrophobicity and net charge of many peptides play a important role in their host defence to invading bacterial pathogens. In vertebrates, the C-terminal portion of TFPI-2 consists of a highly conserved cluster of positively charged amino acids which may point to an antimicrobial activity. Thus a number of selected C-terminal TFPI-2 derived peptides from different species were synthesized and it was found that all of them exert antimicrobial activity against E. coli and P. aeruginosa. The peptide-mediated killing of E. coli was enhanced in human plasma, suggesting an involvement of the classical pathway of the complement. Under in vitro conditions the peptides displayed anti-coagulant activity by modulating the intrinsic pathway of coagulation and in vivo treatment with the mouse derived VKG24 peptide protects mice from an otherwise lethal LPS shock model. Conclusions: Our results suggest that the evolutionary conserved C-terminal part of TFPI-2 is an interesting agent for the development of novel antimicrobial therapies

Well-being resources and mass participation sports events in Pembrokeshire

Mass participation sport events (MPSEs) have grown in popularity. Specifically, in Pembrokeshire, West Wales, participation has seen a continued increase in athlete numbers and events over the last decade. Moreover, extremely high numbers of Pembrokeshire residents are participating in MPSEs. Current research provides a narrow demonstration of the role of MPSEs in supporting health and well-being. A qualitative approach was used as contrast to most methodology in the literature to better understand the embodied experiences of individuals taking part in MPSEs. This article draws on interview data from within a larger study to explore the emerging theme of well-being. Eighteen individuals, 12 females and 6 males, aged between 34 and 58 took part in the research. Findings show that firstly, exercise in several MPSE contexts strengthen psychological resources. Secondly, connections made in MPSEs provide social resources and, finally, nature and the physical environment act as a physical resource. In conclusion, many MPSE contexts, from 5K parkrun to long-distance events, provide an opportunity for people in society to develop resources to support well-being. Further analysis is ongoing to fully explore the contribution that MPSE make to the well-being of athletes and the wider communit

Knowledge and attitude toward theranostics among Nuclear Medicine Technologists

This study was conducted to determine the knowledge and attitude of nuclear medicine technologists toward theranostics. This research utilized a quantitative correlational research design. Data were gathered from 69 practicing nuclear medicine technologists, specifically those that do not perform or have theranostics procedures. The data were gathered using a self-made questionnaire and statistically treated using frequency, percentage, range, mean, standard deviation, t-test, ANOVA, Kruskal-Wallis H test, Mann-Whitney U test, and Spearman Rank Order Correlation. Findings show that the majority of the respondents are male, and most are 20-30 years old. Most of the respondents have good knowledge and show a “positive attitude” toward theranostics. In general, there are no significant differences in the knowledge of the respondents about theranostics when they are grouped according to sex, years of experience and type of hospital they are currently employed in. However, there is a significant difference when grouped according to age, where the 31–40-year-old group showed a higher level of knowledge than the 20-30-year-old group possibly due to learning more about practices with theranostics. With the respondents’ attitude toward theranostics, there are no significant differences when they are grouped according to age, sex, years of experience, and type of hospital they are currently employed in. The findings also show that there is a weak positive relationship between the knowledge and attitude of the respondents toward theranostics. Generally, the results show that nuclear medicine technologists have very good attitude toward and good knowledge of theranostics

a mixed-methods study protocol

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Current knowledge and future prospects of lima bean (Phaseolus lunatus)-rhizobia symbiosis

Lima bean (Phaseolus lunatus) is an important species of the genus Phaseolus for human consumption in tropical regions. The seeds are important source of protein for people from South America, Africa and Mexico. In addition, as a legume plant, lima bean presents the ability to perform the biological nitrogen fixation (BNF) through the symbiosis with nitrogen-fixing bacteria. The studies about diversity and efficiency of lima bean-rhizobia symbiosis have increased worldwide, mainly in Latin America. These studies have shown Bradyrhizobium and Rhizobium as the main symbionts, although Sinorhizobium, Mesorhizobium and Allorhizobium have been found associated with lima bean. Also, there is a large variation in the efficiency of N fixation by the current isolates of rhizobia and some rhizobia have presented high capability for fixing N. This review aims to explore the studies about diversity and efficiency of rhizobia in symbiosis with lima bean.Lima bean (Phaseolus lunatus) is an important species of the genus Phaseolus for human consumption in tropical regions. The seeds are important source of protein for people from South America, Africa and Mexico. In addition, as a legume plant, lima bean presents the ability to perform the biological nitrogen fixation (BNF) through the symbiosis with nitrogen-fixing bacteria. The studies about diversity and efficiency of lima bean-rhizobia symbiosis have increased worldwide, mainly in Latin America. These studies have shown Bradyrhizobium and Rhizobium as the main symbionts, although Sinorhizobium, Mesorhizobium and Allorhizobium have been found associated with lima bean. Also, there is a large variation in the efficiency of N fixation by the current isolates of rhizobia and some rhizobia have presented high capability for fixing N. This review aims to explore the studies about diversity and efficiency of rhizobia in symbiosis with lima bean